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In addition to increasing the activity of MMPs, HIFs increase the production of chondrocyte glycolysis and the mitochondrial activity of chondrocytes under hypoxia, but ultimately leads to chondrocyte death (191)

ALC administration (1 g/day orally for 16 weeks) in patients suffering from FHA ( n = 24, age range 21 to 32 years) was found to increase LH levels by counteracting certain neuroendocrine pathways that have an inhibitory effect on the reproductive axis [17]